Research Interests
Outcomes and Interventions in Congenital Heart Disease, Pregnancy and Heart Disease, Echocardiography in Structural Heart Disease
Research Summary
Research focus is primarily in the area of adult congenital heart disease, pregnancy and heart disease with an imaging component. Interested in outcomes in this populatio with a view to interventions that can improve health and quality of life.
Research Highlights
Personal
Education
University of British Columbia B.Sc. Biochemistry 1992-1996,
University of Manitoba MD Medicine 1997-2001,
University of Manitoba B.Sc. Research 1997-2001,
Harvard University Brigham and Women’s Research Internship 1998-2000,
University of British Columbia Internal Medicine Residency,
McMaster University Cardiology Residency & Chief Resident,
Mayo Clinic, Rochester, Minnesota Clinical Fellowship in Echocardiography 2007-2008,
University of Toronto Clinical Fellowship in Adult Congenital Heart Disease 2008-2009,
Affiliations
Recent Publications
1. Roos-Hesselink J, Parsonage W, DeBacker J, Otto C, Maggioni A, Budts W, Marelli A, Grewal J, Boersma H, Johnson M, Hall R. Pregnancy Outcomes in Women with Cardiovascular Disease:evolving trends over 10 years in the ESC Registry of Pregnancy and Cardiac Disease (ROPAC). Accepted to European Heart Journal 2019.
2. Guenette J, Ramsook AH, Dhillon SS, Puyat JH, Riahi M, Opotowsky A, Grewal J. Ventilatory and sensory responses to incremental exercise in adults with a Fontan Circulation. Am J Physiol Heart Circ Physiol 2019;316 (2):335-344.
3. Silversides C, Grewal J, Mason J, Sermer M, Kiess M,Wald R, Colman J, Siu S. Pregnancy Outcomes in Women with Heart Disease: The CARPREG II study. JACC 2018;71(21):2419-2430.
4. Wilson, W. M, Valente, A. M., Hickey, E.J, Clift, P.,Burchill, L. , Emmanuel, Y, Gibson, P., Greutmann, M. , Grewal, J., Grigg. L.E., Gurvitz, M, Hickey, K., Khairy, P., Mayer Jr., J. E., Teo, E., Vonder Muhll, I., Roche, S.L., Silversides, C.K. and Wald, R. M. Outcomes of hypoplastic left heart syndrome patients reaching adulthood after Fontan palliation: a multicenter study. Circulation 2018;137 (9):978-981.
5. Tong C, Kiess M, Deyell M, Silversides C, Grewal J. Impact of Frequent Premature Ventricular Contractions on Pregnancy Outcomes. Heart 2018; 104(16):1370-1375.
6. Wan D, Tsui C, Kiess M, Grewal J, Krahn A, Chakrabarti S. Anticoagulation for Thromboembolic Risk Reduction in Adults with Congenital Heart Disease. Can J Cardiol 2017; 33(12): 1597-1603.
7. Lee D, Levin A, Kiess M, Sexsmith G, Chakrabarti S, Human D, Barlow A, Grewal J. Chronic Kidney Damage in the Fontan Population. IJC 2018;257:62-66.
8. Wald, R.M., Farkouh, M., Caldarone C., Dahdah, N., Dallaire, F., Drolet, C., Grewal, J., Hickey, E. , Kayedpour ,C., Khairy, P., Leonardi, B. , McCrindle, B., Nadeem, S., Ng, M., Oechslin, E., Redington, A., Silversides, C., Tham, E., Therrien, J., Vonder Muhll, I., Warren, A., Wintersperger, B., Kovacs A. Patient-Reported Outcomes in Tetralogy of Fallot: Baseline Results From a Prospective, International, Multi-Site Study. American Heart Association Journal. November 2017
9. Wald, R.M., Farkouh, M., Caldarone, C., Dahdah, N., Dallaire, F., Drolet, C., Grewal, J., Kayedpour, C., Khairy, P., Kovacs, A., Leonardi, B., McCrindle, B., Nadeem, S., Ng, M., Oechslin. E, Redington, A., Silversides, C, Tham, E, Therrien, J., Vonder Muhll, I, Warren. A., Wintersperger, B., Hickey, E. Baseline Cardiovascular Magnetic Resonance Imaging Measurements Are Associated With Clinical Outcomes at Three Years of Follow-Up: Results From a Prospective, International, Multi-Site Study of Patients With Significant Pulmonary Regurgitation Late After Tetralogy of Fallot Repair. American Heart Association Journal. November 2017.
10. Riahi M, Claman A, Kiess M, Orgad M, Human D, Chakrabarti S, Leipsic J, Grewal J. Longitudinal sequential biventricular assessment in adults with transposition of the great arteries and relationship with adverse outcomes. Int J Cardiol 2017.
11. Tabarsi N, Simmonds J, Toma M, Kiess M, Tsang V, Gao M, Grewal J. Meta-Analysis of the Effectiveness of Heart Transplantation in Patients with a Failing Fontan. Am J Cardiol 2017; 119(8):1269-1274.
12. Editors: Jasmine Grewal and Marla Kiess. Management of the Congenital Heart Disease Patient in British Columbia. THEME ISSUE. BCMJ 2017.
13. Mak G, Blanke P, Naoum C, Moss R, Ong K, Thompson C, Webb J, Grewal J. Three Dimensional Echocardiography Compared with Computed Tomography to determine Mitral Annulus Size before Transcatheter Mitral Valve Implantation. Circ Imaging 2016; 9(6).
14. Naoum C, Leipsic J,Cheung A, Ye J, Bilbey N,Berger A, Dvir D, Arepalli C, Grewal J, Muller D, Murphy D, Hague C, Piazza N, Webb J, Blanke P. Mitral Annular Dimensions and Geometry in Patients With Functional Mitral Regurgitation and Mitral Valve Prolapse. JACC Cardiovasc Imaging 2016;9(3):269-80.
15. Cedars A, Schmidt AS, Broberg C, Zaidi A, Opotowsky S, Grewal J, Kay J, Bhatt AB, Novak E, Spertus J; Alliance for Adult Research in Congenital Cardiology (AARCC). Adult congenital heart disease patients experience similar symptoms of disease activity. Circ Cardiovasc Qual Outcomes 2016; 9(2):161-70.
16. Wijesekera V, Leipsic J, Human D, Barlow A, Chakrabarti S, Kiess M, Grewal J. Sequential LV and RV assessment in tetralogy of Fallot patients with severe pulmonary regurgitation. Congenit Heart Dis 2016.
17. Burchill LJ, Lamejer H, Roos-Hesselink JW, Grewal J, Ruys TP, Kulikowski JD, Burchill LA, Oudijk MA, Wald RM, Colman JM, Siu SC, Pieper PG, Silversides CK. Pregnancy Risks in Women with Pre-Existing Coronary Artery Disease, or Following Acute Coronary Syndrome. Heart 2015; 101(7): 525-529.
18. Wheeler M, Leipsic J, Trinh P, Kiess M, Thompson C, Moss R, Munt B, Grewal J. Right Ventricular Assessment in Adult Congenital Heart Disease Patients with a RV to PA Conduit: Validation of a 3D Knowledge Based Reconstruction Method. J Am Soc Echocardiogr 2015; 28(5): 522-32.
19. Opotowsky A, Moko L, Ginns J, Rosenbaum M, Greutmann M, Aboulhosn J, Hageman A, Kim Y, Deng L, Grewal J, Zaidi A, Almansoori G, Oechslin E, Earing M, Landzberg M, Singh M, Wu F, Vaidya A. Pheochromocytoma and Paraganglioma in Cyanotic congenital Heart Disease. JCEM 2015 Apr; 100(4): 1325-34.
20. Tabarsi N, Levy R, Rychel V, Kiess M, Swiston J, Oakes J, Grewal J. Pregnancy among Women with pulmonary arterial hypertension: A Changing Landscape? Int J Cardiol 2014 Dec; 177(2): 490-491.
21. Wald RM, Altaha MA, Alvarez N, Calderone C, Drolet C, Grewal J, et al. Rationale and Design of the Canadian Outcomes Registry Late after Tetralogy of Fallot Repair: The CORRELATE Study. Can J Cardiol 2014 Nov; 30(11): 1436-43.
22. Wijesekera VA, Kiess M, Grewal J, Chow R, Raju R, Leipsic J, Barlow A. Aortic Dissection in a patient with a dilated aortic root following tetralogy of Fallot repair. Int J Cardiol 2014; 174(3):833-4.
23. Lempereur M, Grewal J, Saw J. Spontaneous coronary artery dissection associated with beta HCG injections and fibromuscular dysplasia. Can J Cardiol 2014; 30(4):464 e 1-3.
24. Grewal J, Silversides CK, Colman JM. Pregnancy in women with heart disease: risk assessment and management of heart failure. Heart Fail Clin 2014; 10(1):117-29.
25. Ong K, Boone R, Gao M, Kiess M, Grewal J. Right ventricular to pulmonary artery conduit reoperations in patients with tetralogy of fallot or pulmonary atresia associated with ventricular septal defect. Am J Cardiol 2013; 111(11):1638-43.
26. Grewal J, Al Hussein M, Feldstein J, Kiess M, Ellis J, Human D, Leipsic J. Evaluation of Silent Thrombus after the Fontan Operation. Congenit Heart Dis 2013; 21(6):40-7.
27. Davis M, Kiess M, Rychel V, Fofonoff D, Grewal J. A case of Starr Edwards Valve Thrombosis in Pregnancy. J Heart Valve Dis 2012; 21(6):783-7.
28. Grewal J, Garceau P, Crean A, Rachowski H, Silversides C. Subaortic right ventricular characteristics and relationship to exercise capacity in congenitally corrected transposition of the great arteries. J Am Society of Echocardiography 2012; 25(11):1215-21.
29. Toggweiler S, Boone RH, Rodés-Cabau J, Humphries KH, Lee M, Nombela-Franco L, Bagur R, Willson AB, Binder RK, Gurvitch R, Grewal J, Moss R, Munt B, Thompson CR, Freeman M, Ye J, Cheung A, Dumont E, Wood DA, Webb JG. Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation. J Am Coll Cardiol. 2012; 59(23):2068-74.
30. Hatton R, Colman J.M, Sermer M, Grewal J, Silversides, C. K. Cardiac risks and management of complications in pregnant women with congenital heart disease. Future Cardiology. 2012; 8(2); 315-327.
31. Piran S, Bassett AS, Grewal J, Swaby JA, Morel C, Oechslin EN, Redington AN, Liu PP, Silversides CK. Patterns of Cardiac and Extra-Cardiac Anomalies in Adults with Tetralogy of Fallot. AM Heart J. Jan 2011; 161(1): 131-7.
32. Olga BH, Siu SC, Mason J, Grewal J, Wald R, Oechslin EN, Kovacs B, Sermer M, Colman JM, Silversides CK. Cardiac Outcomes after Pregnancy in Women with Congenital Heart Disease. Heart. 2010; 96: 1656-1661.
33. Lam C, Grewal J, Borlaug B, Ommen S, Kane G, McCully R, Pellikka P. Size, Shape and Stamina: The Impact of Left Ventricular Geometry on Exercise Capacity. Hypertension. May 2010; 55(5): 1143 -1149.
34. Grewal J, Suri RM, Mankad S, Miller F, Schaff HV, Enriquez-Sarano M. Mitral Annular Dynamics in Myxomatous Valve Disease: New Insights with Real-Time 3-Dimensional Echocardiography. Circulation. Mar 2010; 121: 1423 – 1431.
35. Grewal J, Siu S, Ross H, Mason J, Balint O, Sermer M, Colman J, Silversides C. Pregnancy Outcomes in Women with Dilated Cardiomyopathy. J Am Coll Cardiol 2010;55:45-52.
36. Grewal J, Mankad S, Miller F, Click R, Freeman W, Suri R, Oh J. Real-Time Transesophageal Echocardiography in the Intraoperative Assessment of Mitral Valve Disease. JASE 2009 Jan 22; (1):34-41.
37. Grewal J, Kane G, McCully R, Lam C, Pellikka P. Left Ventricular Function and Exercise Capacity. JAMA 2009 Jan 21; 301(3):286-94.
38. Grewal J, Majdalany D, Syed I, Pellikka P, Warnes C. 3D Right Ventricular Assessment in Tetralogy of Fallot Repair Patients. J Am Society Echocardigraphy. Feb 2010; 23(2): 127-133.
39. Greutmann M, Tobler D, Grewal J, Biaggi P, Oechslin E, Silversides C. A reminder from the past: a 49 year old patient with Transposition of the Great Arteries palliated with Dr.Thomas Baffe’s and Dr.Wiliam Mustard’s original operations. JASE 2009;22(11):1310.
40. Grewal J, Suri RM, Mankad S, Enriquez-Sarano M, Miller FA, Schaff HV. Is the anterior trigonal distance increased in patients with mitral regurgitation due to leaflet prolapsed? Ann Thorac Surg 2009;88(4):1202-1208.
41. Grewal J, Anand S, Islam S, Lonn E. Predictors of Subclinical Atherosclerosis among Asymptomatic “Low Risk” Individuals. Atherosclerosis 2008;197:435-42.
42. Grewal J, McKelvie R, Lonn E, Persson H. BNP and NT-proBNP predict echocardiographic severity of diastolic dysfunction. Eur J Heart Failure 2008;10:252-9.
43. Grewal J, McKelvie R, Persson H, Lonn E. Usefulness of N-terminal pro-BNP and BNP to predict Cardiovascular Outcomes in Patients with Heart Failure and Preserved Left Ventricular ejection Fraction. Am J Cardiol 2008;102:733-737.
44. Lonn E, Grewal J. Drug therapies in the Secondary Prevention of Cardiovascular Diseases: Successes, Shortcomings and Future Directions. Current Vascular Pharmacology 2006; 4(3): 1-16.
45. Grewal J, Lonn E. Surrogates of surrogates: the story of hypertension and 24 hour blood pressure monitoring. Can J Cardiology 2005;21(8):639-42.
46. Grewal J, Lonn E. The ABC’s of Secondary Cardiovascular Prevention: the successes and what we need to obtain now. Dialogues in Cardiovascular Medicine 2005; 10 (4): 209-232.
47. Grewal J, Chandavimo M, Ignazewski, A. BNP: A Review. B.C. Medical Journal. January 2004;46(1):24-29.
48. Grewal J, Gin K. Troponin Utility. Perspectives in Cardiology. May 2004;35-40.
49. Grewal J, Chan S, Frohlich J, Mancini GBJ. Assessment of Novel Risk Factors in Patients at Low Risk for Cardiovascular Events Based on Framingham Risk Stratification. October 2003. Clin Inv Med.
50. Kinlay S, Grewal J, Ganz P. Coronary flow velocity and disturbed flow, predict adverse clinical outcome after coronary angioplasty. Atherosclerosis Thrombosis Vascular Biology. August 2002;22(8):1334-40:1.
51. Grewal, J., Ganz, P., Selwyn, A., Kinlay, S. Usefulness of Intravascular Ultrasound in preventing stenting of hazy areas adjacent to coronary stents: A strategy to prevent spot stenting. American Journal of Cardiology. June 2001;87(11):1246-9.
52. Tam, B.M., Grewal, J., He, S., Shewry, S., Murphy, M., & MacGillivray, RTA. X-Ray Crystallography and Mass Spectroscopy reveal that the N-lobe of Human transferrin expressed in Pichia Pastoris is folded correctly but glycosylated on Serine-32. Biochemistry, 1999; 38: 2535-2541.
Awards & Recognition
- 2008 AHA Best of the Best Web Broadcast – Age and Gender Implications of Diastolic Function on Exercise Capacity.
- 2008 Cardiosource Mention – Age and Gender Implications of Diastolic Function on Exercise Capacity.
- 2009 Reuters Health Interview/Article – Pregnancy Outcomes in Dilated Cardiomyopathy.
- 2009 Cardiosource Mention – Pregnancy Outcomes in Dilated Cardiomyopathy
- 2010-2012 Providence Health Care – Physician Scholar Award
Grants
- 2017-2019 Division of Cardiology Pilot Study Funds – Cardiovascular Outcomes in Turner Syndrome Pregnancies ($28,000/year)
- 2017-2020 Heart and Stroke Foundation – Chronic Kidney Damage in the Fontan Population ($282,000)
- 2017 Rare Disease Foundation – Cardiovascular Outcomes of Pregnancy in Turner Syndrome: A Multi-Center Retrospective Case-Control Study ($3,500/year)
- 2014-2015 Partnerships for Health System Improvement – Optimizing Care for Adults with Congenital Heart Disease – Targeting Patient at High Risk for Heart Failure Hospitalizations ($400,000/year)
- 2014 UBC Division of Cardiology Pilot Study Funds – Evaluation of CKD in the Fontan Population ($28,000/year)
- 2013 Rare Disease Foundation – Outcomes in the Adult Fontan Population ($7,000/year)
- 2010 Physician Scholar Award: Providence Health Care Research Institute – (a) Predictors of Aortic Dilation among Adults with Bicuspid Aortic Valve: A Sub Study of Effects of Beta Blocker and Angiotensin Receptor Blocker on Aortic Dilation in Adults with Bicuspid Aortic Valve (b) Prevalence and Impact of Thromboembolic Phenomena in Adults after the Fontan Procedure: A Prospective Study ($50,000/year for 2 years)
- 2006 McMaster University New Investigator Fund Grant – Bicuspid Aortic Valve: A Risk Factor for Vascular Disease? ($17,000/year)
Operating Grants
- CIHR Congenital Heart Disease across the Lifespan: Improving Quality of Care with Health Services Interventions
- CIHR Correlate Registry
- CIHR Optimizing Care for Adults with Congenital Heart Disease – Targeting Patient at High Risk for Heart Failure Hospitalizations
2019 – date Nate Moulson-Cardiology Fellow
2019 – date Alice Chang-Cardiology Fellow
2019 – date Ben Chen-Medical Student
2018 – date Sherry Sandhu-Medical Student
2018 – date Louis-Phillipe David-Echo Fellow
2016 – date Gnalini Soumarinthan-Echo Fellow
2016 – 2017 Tony Verma-Cardiology Fellow
2015 – date Niall Johal-Medical Student
2015 – 2017 Merav Dvir-Ogad-PACH Fellow
2015 – 2017 Mounir Riahi-PACH Fellow
2014 – 2016 Calvin Tong-Internal Medicine Resident
2014 – 2016 Dana Lee-Cardiology Fellow
2014 – 2015 George Mak-Fellow
2014 – 2017 Michael Qui-Medical Student
2014 – 2015 Nicole Bailey-Masters Student
2013 – 2016 Nazlee Tabarsi-Medical Student