Recent Publications

• Tammemagi M, Lam S, McWilliams A, Sin D. Incremental value of pulmonary function and sputum DNA image cytometry in lung cancer risk prediction. Cancer Prev res (Phila). 2011 Apr;4(4):552-61. Epub 2011 Mar 16.
• Short M, Lam S, McWilliams A, Ionescu D, Zeng H. Using laser Raman spectroscopy to reduce false positives of autofluorescence bronchoscopies:  a pilot study. J Thorac Oncol. 2011 Jul;6(7):1206-14.
• McDonough J, Yuan R, Suzuki M, Seyednejad N, Elliott W, Sanchez P, Wright A, Gefter W, Litzky L, Coxson H, Pare P, Sin D, Pierce R, Woods J, McWilliams A, Mayo J, Lam S, Cooper J, Hogg J. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med. 2011 Oct 27;365(17):1567-75.
• Ahn M, Gleeson T, Chan I, McWilliams A, Macdonald S, Lam S, Atkar-Khattra S, Mayo J.  Perifissural nodules seen at CT screening for lung cancer.  Radiology. 2010 Mar;254(3):949-56.
• Ishizumi T, McWilliams A, MacAulay C, Gazdar A, Lam S.  Natural history of bronchial preinvasive lesions.  Cancer Metastasis Rev. 2010 Mar;29(1):5-14.
• Gustafson A, Soldi R, Anderlind C, Scholand M, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion P, Lenburn M, Lam S, Bild A, Spira A.  Airway P13K pathway activation is an early and reversible event in lung cancer development.  Sci Transl Med. 2010 Apr 7;2(26):26ra25.
• Tkacova R, McWilliams A, Lam S, Sin D.  Integrating lung and plasma expression of pneumo-proteins in developing biomarkers in BOPD:  a case study of surfactant protein D.  Med Sci Monit. 2010 Nov;16(11):CR540-4.
• Yee J, Sadar M, Sin D, Kuzyk M, Xing L, Kondra J, McWilliams A, Man S, Lam S.  Connective tissue-activating peptide III:  a novel blood biomarker for early lung cancer detection.  J Clin Oncol.  2009 Jun 10;27(17):2787-92. Epub 2009 May 4.
• Edell E, Lam S, Pass H, et al.  Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence – reflectance bronchoscopy:  an international, multi-centre clinical trial.  J Thorac Oncol.  2009 Jan;4(1):49-54.
• Lane P, Lam S, McWilliams A, LeRiche J, Anderson M, MacAulay C.  Confocal fluorescence microendoscopy of bronchial epithelium.  J Biomed Opt. 2009 Mar-Apr;14(2):024008.
• Mayo J, Clifton J, Powell T, et al.  Lung nodules:  CT-guided placement of microcoils to direct video-assisted thorascopic surgical resection.  Radiology. 2009 Feb;250(2):576-85.
• McWilliams A. Early proximal lung cancer diagnosis and treatment.  Accepted to European Respiratory Journal, 2009.
• Lee P, vanden Berg R, Lam S, Gazdar A, Grunberg K, McWilliams A, Leriche J, Postmus P, Sutedja T.  Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ.  Clin Cancer Res. 2009 Jul 15;15(14):4700-5. Epub 2009 Jul 7.
• Sheel A, Guenette J, Yuan R, Holy L, Mayo J, McWilliams A, Lam S, Coxson H.  Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers.  J Appl Physiol. 2009 Nov;107(5):1622-8.  Epub 2009 Sep 17.
• Chen J, Lam S, Pilon A, McWilliams A, MacAulay C, Szabo E.  Higher Levels of the Anti-inflammatory Protein CC10 are Associated with Improvement in Bronchial Dysplasia and Sputum Cytometric Assessment in Individuals at High Risk for Lung Cancer.  Clin Can Res. 2008 Mar 1;14(5):1590-7.
• Coxson H, Quiney B, Sin D, et al.  Airway wall thickness assessed using Computed Tomography and Optical Coherence Tomography.  Am J Resp and Crit Care Med.  2008 Jun 1;177(11):1201-6. Epub 2008 Feb 28.
• Godoy MCB, Cooperberg P, Maizlin Z, et al.  Detection Sensitivity of a commercial Lung Nodule CAD System in a Series of Pathologically Proven Lung Cancers.  J Thorac Imaging. 2008 Feb;23(1):1-6.
• Jonsson S, Varella-Garcia M, Miller Y, et al.  Chromosomal Aneusomy in Bronchial High Grade Lesions is Associated with Invasive Lung Cancer.  Am J Respir Crit Care Med.  2008 Feb 1;177(3):342-7. Epub Nov 7.
• McWilliams A, Mayo J.  Computed tomography-detected noncalcified pulmonary nodules: a review of evidence for significance and management.  Proc Am Thorac Soc. 2008 Dec 15;5(9):900-4.  Review.
• Short M, Lam S, McWilliams A, Zhao J, Lui H, Zeng H.  Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers.  Opt Lett. 2008 Apr 1;33(7):711-3.
• Sin D, Man P, McWilliams A, Lam S.  Surfactant Protein D and Bronchial Dysplasia in Smokers at High Risk of Lung Cancer.  Chest. 2008 Sep;134(3):582-8.
• Zeng H, Fawzy Y, Short M, et al.  Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection.  Conf Proc IEEE Eng Med Biol Soc. 2008:1849-50.
• Zeng H, Zhao J, Short M, et al.  Raman spectroscopy for in vivo tissue analysis and diagnosis, from instrument development to clinical applications.  J Innovation in Opt Health Sciences. 2008; 1(1):95-106.
• Chen J, Lam S, Pilon A, McWilliams A, Melby J, Szabo E.  The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.  Cancer Epidemiol Biomarkers Prev.  2007 Mar;16(3):577-83.
• Kennedy TC, McWilliams A, Edell E, et al.  Bronchial Intraepithelial Neoplasia/Early Central Airways Lung Cancer:  ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition).  Chest.  September 2007:132(3 suppl);221S-233S.
• Yuan R, Mayo JR, Hogg JC, et al.  The effects of radiation dose and computed tomography manufacturer on measurements of lung densitometry.  Chest.  2007 August:132;617-623. [Epub ahead of print].
• Cox G, Miller J, McWilliams A, Fitzgerald M, Lam S.  Bronchial Thermoplasty™ For Asthma. Am J Respir Crit Care Med.  2006 May 1;173(9):965-9.  Epub 2006 Feb 2.
• Lam S, McWilliams A, LeRiche JC, MacAulay C, Szabo E. A Phase I Study of myo-inositol for lung cancer chemoprevention.  Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31.
• Lam S, Standish B, Baldwin C, McWilliams A, LeRiche J, Gazdar A, Vitkin A, Yang V, Ikeda N, MacAulay C.  In-vivo Optical Coherence Tomography Imaging of Pre-invasive Bronchial Lesions.  Clin Can Research. 2008 Apr 1;14(7):2006-11.
• McWilliams A, Mayo J, Ahn MI, MacDonald S, Lam, S.  Lung Cancer Screening Using Multi-Slice Thin-Section Computed Tomography and Autofluorescence Bronchoscopy.  J Thoracic Oncology 2006;1(1):61-68.
• Shaipanich T, McWilliams A, Lam S. Early Detection and Chemoprevention of Lung Cancer.  Respirology. 2006 Jul;11(4):366-72.
• Sin D, Man P, McWilliams A, Lam S.  Progression of Airway Dysplasia and C-reactive Protein in Smokers at High Risk of Lung Cancer.  Am J Respir Crit Care Med.. 2006;173:535-539.